population based prevention

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We take your privacy seriously. doi: 10.1023/A:1020807613155. Updated for FY 2022, this resource contains information to help you prepare and submit applications for OJP funding and offers guidance on award administration. 0000003343 00000 n Biglan A., Metzler C. A public health perspective for research on family-focused interventions. Treasure Island (FL): StatPearls Publishing; 2022 Jan. This study examined population health literacy levels and health trends from 2012 to 2018. NCJ Number 255453 Journal Prevention Science Issue: 10 Dated: 2009 Pages: 1-12 Author (s) Ronald J. Prinz; Matthew R. Sanders; Cheri J. Shapiro; Daniel J. Whitaker; John An official website of the United States government. Addresses the broad determinants of health. Best Pract Res Clin Obstet Gynaecol. Manchanda R, Patel S, Antoniou AC, Levy-Lahad E, Turnbull C, Evans DG, Hopper JL, Macinnis RJ, Menon U, Jacobs I, Legood R. Am J Obstet Gynecol. The https:// ensures that you are connecting to the Leveraging behavioral economics and implementation science to engage patients at risk for suicide in mental health treatment: a pilot study protocol. WebIn population-based nursing, theory helps explain and organize relationships among intervention. In the introductory section, existing research on the epidemiology of dieting is reviewed, showing that it is extremely common among adolescent girls and women and that the behavior has been implicated as a causal factor for disordered eating. 2021 Oct 1;12(5):1996-2022. doi: 10.1093/advances/nmab026. The validation of these results in real-world population-based studies is therefore valuable to assess the relevance and the effectiveness of treatment guidelines for the prevention of pre-eclampsia. MEDLINE, EMBASE, Pubmed, CINAHL and PsychINFO databases were searched using free-text and MeSH terms; retrieved reference lists of publications were screened; additionally, web-based platforms, Google, and clinical-trial registries were searched. Recruitment is underway in three health systems (Group Health Cooperative, HealthPartners, and Kaiser Permanente Colorado). How is Population Health Different from Public Health? It also shifts the goal of practitioners to behavioral wellness and not just the absence of Correlation between mean body mass index in the population and prevalence of obesity in Brazilian capitals: empirical evidence for a population-based approach of obesity. 8600 Rockville Pike The efficacy of the Triple PPositive Parenting Program in improving parenting and child behavior: A comparison of two other treatment conditions. WebPopulation-Based Prevention of Child Maltreatment: The U.S. Unauthorized use of these marks is strictly prohibited. 2005 Mar;159(3):225-30. doi: 10.1001/archpedi.159.3.225. Careers. -. Australian e-Journal for the Advancement of Mental Health, 2. In the case of eating disorders, Rose's model is instructive: Dieting stands out as risk behavior that may both fit Rose's model well and be a key leverage point for preventive intervention. Trial registration: PMC low physical activity and unbalanced and western-style diets), which leads to a low-grade inflammatory state and an increase in oxidative stress, due to an unbalanced ratio of pro-oxidants and Bookshelf Clipboard, Search History, and several other advanced features are temporarily unavailable. (PO 4 and 8) CO 4: Evaluate the delivery of care for individuals, families, aggregates, and communities based on theories doi: 10.1016/j.ajog.2017.06.038. The impact of a school-based obesity prevention trial on disordered weight-control behaviors in early adolescent girls. The site is secure. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Translating etiologic theory into community health interventions depends on the identification of key leverage points, factors that are amenable to public health intervention and provide an opportunity to maximize impact on the outcome of interest. 0000003657 00000 n J. Clin. Public Health Nurs. Epub 2019 Mar 13. Biglan A. Translating what we know about the context of antisocial behavior into a lower prevalence of such behavior. "Population-Based Prevention of Obesity" recommends an approach that would complement individually-oriented strategies, including clinic-based prevention and treatment programs. 2022;28(4):721-738. doi: 10.1080/13575279.2021.1933902. This approach addresses the need to get upstream as it promotes intervention before individuals need clinical services. 2016;77(2):2217. Bookshelf Intersectoral action involves engaging -, OConnor E, Gaynes BN, Burda BU, Soh C, Whitlock EP. Transl Behav Med. Slawson DL, Dalton WT 3rd, Dula TM, Southerland J, Wang L, Littleton MA, Mozen D, Relyea G, Schetzina K, Lowe EF, Stoots JM, Wu T. Contemp Clin Trials. HTQj0+L$r&])=H;Z0;h8C{q"{ptD_Fh[sO}v5:?|Rc3d^N /f@L.H*. A Skills Training intervention includes interactive online training in Dialectical Behavior Therapy skills, supported by reminder and reinforcement messages from a skills coach. Method: This population-based cohort study enrolled patients aged 60-89 years using data from the Health Insurance Review and Assessment database of South Korea between 2009 and 2018. %PDF-1.4 % Lobato JC, Kale PL, Velarde LG, Szklo M, Costa AJ. F.G. declares no conflict of interest. Would you like email updates of new search results? Matern Child Health J. Study Design and Population This study was performed as part of the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort study, which is a large-scale, prospective population-based cohort study that commenced in 1997 in Groningen, the Netherlands [ 17 ]. Cann, W., Rogers, H., & Matthews, J. 2022 Apr 19;12(5):1028. doi: 10.3390/diagnostics12051028. Share sensitive information only on official, secure websites. Health Educ Res. 0000010780 00000 n 05-2008. 2019 Jan;23(1):109-119. doi: 10.1007/s10995-018-2600-4. sharing sensitive information, make sure youre on a federal 0000026169 00000 n Unable to load your collection due to an error, Unable to load your delegates due to an error. KOL Key Opinion Leaders & Influencers . Use the wide variety of artworkincluding, posters, fliers, web and social graphics, and morein your campaigns to raise awareness about victims rights and services. Each intervention and practice level contributes to improving population health. In: National Vital Statistics Reports. 2021 Mar 22;4(1):158-165. doi: 10.1136/bmjnph-2020-000211. Considers multiple levels of prevention with preference for primary prevention. National Library of Medicine These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. A .gov website belongs to an official government organization in the United States. Duval S, Van't Hof JR, Oldenburg NC, Eder M, Finnegan JR Jr, Luepker RV. P60 DK020572/DK/NIDDK NIH HHS/United States, P60 DK020572-269021/DK/NIDDK NIH HHS/United States, P60 DK-20572/DK/NIDDK NIH HHS/United States. We defined PMC 2023 Jan;52(1):217-231. doi: 10.1007/s10508-022-02328-1. 0000013700 00000 n Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; Coordinating Committee of the National Cholesterol Education Program. Journal of Abnormal Child Psychology. Sawaguchi E, Nakamura S, Watanabe K, Tsuno K, Ikegami H, Shinmura N, Saito Y, Narimatsu H. Front Public Health. 8600 Rockville Pike 2015 Jul;43:39-52. doi: 10.1016/j.cct.2015.04.012. Population panel testing for BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 gene mutations is the most cost-effective genetic-testing strategy in general-population women and can prevent thousands more breast and ovarian cancers than current clinical-criteria based approaches. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). and transmitted securely. Complex systems approaches are increasingly used in health promotion and noncommunicable disease prevention research, policy and practice. 2021 Aug 26;18(17):8980. doi: 10.3390/ijerph18178980. Do early childhood interventions prevent child maltreatment? Epub 2021 Oct 18. An official website of the United States government. Drug abuse prevention through family interventions. Accessibility This site needs JavaScript to work properly. Part II. and transmitted securely. PMC 2018 Jul 31;19(1):410. doi: 10.1186/s13063-018-2796-z. National Hospital Ambulatory Medical Care Survey: 2008 Emergency Department Summary Tables. The LDL-targeted strategy and the low-intensity population-based strategy were comparable for CV events prevented over five years (0.79 million and 0.75 million, respectively), as were the risk-targeted strategy and moderate-intensity population-based strategy (1.56 million and 1.87 million, respectively). Bethesda, MD 20894, Web Policies eCollection 2022. Secure .gov websites use HTTPS Epidemiological studies of suicide and intervention studies in selected risk groups. Disclaimer. National Library of Medicine Disclaimer. government site. Variation in the net benefit of aggressive cardiovascular risk factor control across the US population of patients with diabetes mellitus. FOIA Official websites use .gov Nonfatal suicide attempts lead to over 200,000 hospitalizations and 600,000 emergency department visits annually. government site. 0000002692 00000 n Lee KM, Dias GM, Boluk K, Scott S, Chang YS, Williams TE, Kirkpatrick SI. WebThis article sets out how the prevention of child maltreatment can be enhanced by a multi-level population-based approach in providing evidence- based parenting and family support. Suicide attempts and deaths following randomization are identified using state vital statistics data and health system EHR and insurance claim data. 2015 Apr 2;15:322. doi: 10.1186/s12889-015-1637-1. 0000010274 00000 n We limited our review to studies conducted in non-health care settings and excluded studies that focused on pharmacologic treatments or psychotherapy. Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction: A Qualitative Study Using Semi-Structured Interviews. Bodenmann, G., Cina, A., Ledermann, T., & Sanders, M. R. (2008). 0000032306 00000 n The prevention of child maltreatment necessitates a public health approach. and transmitted securely. An official website of the United States government. Careers. 0000002303 00000 n WebA population-based prevention strategy can be an excellent option if an intervention has almost no adverse effects. Whitfield MD, Gillett M, Holmes M, Ogden E. Public Health. Razak F, Subramanian SV, Sarma S, Kawachi I, Berkman L, Davey Smith G, Corsi DJ. -, Simon GE, Coleman KJ, Rossom RC, Beck A, Oliver M, Johnson E, Whiteside U, Operskalski B, Penfold RB, Shortreed SM, et al. Methods: 0000032166 00000 n Federal government websites often end in .gov or .mil. Complex systems approaches are increasingly used in health promotion and noncommunicable disease prevention research, policy and practice. Bethesda, MD 20894, Web Policies Quality of studies was evaluated using appropriate check-lists. 2022 Nov 14;29(12):2023-2031. doi: 10.1093/jamia/ocac144. to achieve positive health outcomes. 2022 Dec 12;14(24):6113. doi: 10.3390/cancers14246113. Unauthorized use of these marks is strictly prohibited. But if the intervention has even a small degree of disutility, a targeted approach using multivariable risk prediction can prevent more morbidity and 2002;30:571587. Please enable it to take advantage of the complete set of features! These cases, which address recommended core competencies in prevention education, have been taught to both medical students and preventive medicine residents. 8600 Rockville Pike The Behavioral Risk Factor Surveillance System (BRFSS) in Kansas added health literacy questions to the survey in 2012. Simon GE, Shortreed SM, Boggs JM, Clarke GN, Rossom RC, Richards JE, Beck A, Ahmedani BK, Coleman KJ, Bhakta B, Stewart CC, Sterling S, Schoenbaum M, Coley RY, Stone M, Mosholder AD, Yaseen ZS. 8600 Rockville Pike The 2023 NCVRW theme artwork is now available to download! ) or https:// means youve safely connected to the .gov website. official website and that any information you provide is encrypted See this image and copyright information in PMC. 0000009199 00000 n Improving pragmatic clinical trial design using real-world data. This paper discusses an economic perspective 1995;28:479492. sharing sensitive information, make sure youre on a federal Before Triple P System Population Trial, 18 counties were randomly assigned to either dissemination of the Triple P-Positive Parenting Program system or to the services-as-usual control condition. Federal government websites often end in .gov or .mil. Ma T, Tellegen CL, McWilliam J, Sanders MR. Adm Policy Ment Health. Disclaimer. Journal of Applied Behavior Analysis. See this image and copyright information in PMC. Does Context and Adversity Shape Sexual Behavior in Youth? 2017;317:24022416. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. You can review and change the way we collect information below. Part II provides examples of the innovative ways that the Intervention Wheel is being used in public health/public health nursing practice, education, and administration. Int J Environ Res Public Health. Conclusions: official website and that any information you provide is encrypted The site is secure. This study is the first to randomize geographical areas and show preventive impact on child maltreatment at a population level using evidence-based parenting interventions. ClinicalTrials.gov registration # NCT02326883 , registered on 23 December 2014. The site is secure. However, its impact in a real-world population has not been fully assessed. MacMillan HL; Canadian Task Force on Preventive Health Care. Byker Shanks C, Calloway EE, Parks CA, Yaroch AL. Thank you for taking the time to confirm your preferences. Preventive health care, 2000 update: prevention of child maltreatment. The DHHS (1994a) described population-based public health services as interventions aimed at Nelson HD, Huffman LH, Fu R, Harris EL, Walker M, Bougatsos C. Rockville (MD): Agency for Healthcare Research and Quality (US); 2005 Sep. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2008 Feb. Report from Norwegian Knowledge Centre for the Health Services (NOKC) No. But if the intervention has even a small degree of disutility, a targeted approach using multivariable risk prediction can prevent more morbidity and mortality while treating many fewer people. This site needs JavaScript to work properly. government site. This paper discusses an economic perspective Our results suggest that prevention and appropriate treatment of scrub typhus should be emphasized as a dementia prevention measure. Cancer Inst. They help us to know which pages are the most and least popular and see how visitors move around the site. Disclaimer. Gaba F, Oxley S, Liu X, Yang X, Chandrasekaran D, Kalsi J, Antoniou A, Side L, Sanderson S, Waller J, Ahmed M, Wallace A, Wallis Y, Menon U, Jacobs I, Legood R, Marks D, Manchanda R. Diagnostics (Basel). The https:// ensures that you are connecting to the Evaluating the impact of results-based motivating system on noncommunicable diseases risk factors in Iran: Study protocol for a field trial. A population-based prevention strategy can be an excellent option if an intervention has almost no adverse effects. But if the intervention has even a small degree of disutility, a targeted approach using multivariable risk prediction can prevent more morbidity and mortality while treating many fewe 0000012667 00000 n Data support change in guidelines for population-based BRCA-testing in the Jewish population. 2014 Sep-Oct;20(5):18-23. 2005 Jul-Aug;22(4):347-53. doi: 10.1111/j.0737-1209.2005.220411.x. It can be defined as what we as a society do collectively to assure the conditions in which people can be healthy (Institute of Medicine, 1988). Characteristics, Classification, and Prevention of Child Maltreatment Fatalities. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Population genetic-testing can overcome 0000010739 00000 n doi: 10.1093/humrep/dem055. Discussion: Assessing the effectiveness of population-based suicide prevention requires adherence to the principles of pragmatic trials: population-based enrollment, accepting variable treatment participation, assessing outcomes using health Using an Attributes Model is one way to understand complex Prevention of suicide and attempted suicide in Denmark. 0000021814 00000 n Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. declares research funding from The Eve Appeal and Cancer Research UK into population testing and from Barts & the London Charity and Rosetrees Trust outside this work, as well as an honorarium for grant review from Israel National Institute for Health Policy Research. and transmitted securely. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. 0000001226 00000 n 2020 May;65:139-153. doi: 10.1016/j.bpobgyn.2020.02.007. 2010 Jun 28;170(12):1037-44. doi: 10.1001/archinternmed.2010.150. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Large effect sizes were found for three independently derived population indicators: substantiated child maltreatment, child out-of-home placements, and child maltreatment injuries. Epub 2008 Feb 8. trailer << /Size 123 /Info 87 0 R /Root 92 0 R /Prev 405629 /ID[] >> startxref 0 %%EOF 92 0 obj << /Type /Catalog /Pages 86 0 R /Metadata 88 0 R /AcroForm 93 0 R >> endobj 93 0 obj << /Fields [ ] /DR << /Font << /ZaDb 52 0 R /Helv 53 0 R >> /Encoding << /PDFDocEncoding 54 0 R >> >> /DA (/Helv 0 Tf 0 g ) >> endobj 121 0 obj << /S 497 /T 617 /V 673 /Filter /FlateDecode /Length 122 0 R >> stream eCollection 2022. 2020 Aug;17(4):394-401. doi: 10.1177/1740774520910367. WebPublic health works to protect and improve the health of communities through policy recommendations, health education and outreach, and research for disease detection and injury prevention. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. Share sensitive information only on official, secure websites. Jacobi C, Morris L, Beckers C, Bronisch-Holtze J, Winter J, Winzelberg AJ, Taylor CB. We defined If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Helme-Guizon A, Gavard-Perret ML, Shankland R, Flaudias V. Int J Environ Res Public Health. 2012 Aug;102(8):1600-6. doi: 10.2105/AJPH.2011.300479. Health Promot Int. Epub 2022 Sep 12. Dissemination involved Triple P professional training for the existing workforce (over 600 service providers), as well as universal media and communication strategies. DPH focuses on prevention strategies for specific populations and settings, facilitates the development and use of innovative public health programs and data analytics, undertakes prevention research, and advances evidence-based practices. eCollection 2021 Jun. Outpatients who are at risk of suicide attempt are automatically identified using data from electronic health records (EHRs). College students as facilitators in reducing adolescent obesity disparity in Southern Appalachia: Team Up for Healthy Living. 2007 Mar;40(2):114-9. doi: 10.1002/eat.20344. Accessibility Epub 2006 Nov 3. Self-Efficacy Mediates the Effect of Framing Eating Disorders Prevention Message on Intentions to Have a Sufficient Weight: A Pilot Study. Obes Rev. Mil Med. Interventions are delivered primarily by secure messaging through EHR patient portals. Keller LO, Strohschein S, Schaffer MA, Lia-Hoagberg B. The targeted prevention involves identifying and serving individuals at higher risk . Unable to load your collection due to an error, Unable to load your delegates due to an error, Relationship between Serum LDL and Five-Year Risk of CV Events and Mortality for 4,922 Individuals in NHANES III. Keywords: -, Cuzick J., Sestak I., Bonanni B., Costantino J.P., Cummings S., DeCensi A., Dowsett M., Forbes J.F., Ford L., LaCroix A.Z., et al. The site is secure. Using predictive analytics to improve pragmatic trial design. Clin Trials. CDC views population health as an interdisciplinary, customizable approach that allows health departments to connect practice to policy for change to happen locally. Suicidal thoughts and behaviors among adults aged 18 years - United States, 20082009. Conclusions: Addendum to "Population-Based Prevention of Child Maltreatment: The U.S. Published on 28.2.2023 in Vol 25 (2023) Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/40961, first published July 11, 2022 . BMC Public Health. FOIA Would you like email updates of new search results? Association between population mean and distribution of deviance in demographic surveys from 65 countries: cross sectional study. 2022 Dec 12;23(1):994. doi: 10.1186/s13063-022-06923-4. MeSH The Population Health Training in Place Program (PH-TIPP) is paused and not accepting applications at this time. This study is the first to randomize geographical areas and show preventive impact on child maltreatment at a population level using evidence-based parenting interventions. 0000014736 00000 n Family Intervention Service program evaluation: A brief report on initial outcomes for families. Clipboard, Search History, and several other advanced features are temporarily unavailable. Jukarainen S, Kiiskinen T, Kuitunen S, Havulinna AS, Karjalainen J, Cordioli M, Rm JT, Mars N; FinnGen; Samocha KE, Ollila HM, Pirinen M, Ganna A. Nat Med. WebThe goal of creating evidence-based programs is to scale them at sufficient breadth to support population-level improvements in critical outcomes. 2018 Jul 1;110(7):714-725. doi: 10.1093/jnci/djx265. doi: 10.1200/JCO.2004.04.188. Results: Among Would you like email updates of new search results? Accessibility 0000022205 00000 n Grounded in Rose's work, this article lodges a theoretical argument for the population-based prevention of eating disorders. Physicians seeking certification in the specialty of Public Health and General Preventive Medicine should apply to the Mid-career 12-month Residency. A population-based prevention strategy can be an excellent option if an intervention has almost no adverse effects. Lima SM, Nazareth M, Schmitt KM, Reyes A, Fleck E, Schwartz GK, Terry MB, Hillyer GC. Bookshelf Cost-effectiveness of population based BRCA testing with varying Ashkenazi Jewish ancestry. JAMA. Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancer. Public Health Nurs. An official website of the United States government. 2009;101:8087. -, Bor W., Sanders M. R., Markie-Dadds C. The effects of the Triple PPositive Parenting Program on preschool children with co-occurring disruptive behavior and attentional/hyperactive difficulties. The critique also produced basic steps and best practices for each of the 17 interventions. Please return to this page for updates. 2021 May 24;35:66. doi: 10.47176/mjiri.35.66. 430458. WebBackground: Many clinical trials have reported that low-dose aspirin decreases the risk of pre-eclampsia in women with prior pre-eclampsia. In the U.S. A .gov website belongs to an official government organization in the United States. The purpose of this review was to examine the published literature on the effectiveness and harms of community-based or population-level strategies aimed at preventing suicide. See this image and copyright information in PMC. Unable to load your collection due to an error, Unable to load your delegates due to an error. Prev Sci. Public Health Nurs. HHS Vulnerability Disclosure, Help vol. Results: Following a modified Zelen design, all those identified are assigned to continued usual care (i.e., no contact) or to be offered one of two population-based outreach programs. The theme for National Crime Victims Rights Week (NCVRW) 2023Survivor Voices: Elevate. HHS Vulnerability Disclosure, Help -. National Library of Medicine CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Arch Pediatr Adolesc Med. Online ahead of print.ABSTRACTBACKGROUND: Many clinical trials have reported that low-dose aspirin decreases the risk of pre-eclampsia in women with prior pre-eclampsia. 0000021275 00000 n Population-based public health nursing interventions: a model from practice. Method: We analyzed individuals who underwent GC screening between 2013 and 2014 and received H. pylori eradication therapy before screening. Questions emerge as to the best ways to take a complex systems approach, specifically with respect to population physical activity (PA). 2013;158(10):74154. WebBACKGROUND: Many clinical trials have reported that low-dose aspirin decreases the risk of pre-eclampsia in women with prior pre-eclampsia. Population health brings significant health concerns into focus and addresses ways that resources can be allocated to overcome the problems that drive poor health conditions in the population.. 0000009652 00000 n Parenting and parenting resources among Chinese parents with children under three years of age: rural and urban differences. One of the biggest issues for the field is the reduction in effect sizes seen when a program is taken to scale. From the 20082011 Korea National Health In: Ashery R. S., Robertson E. B., Kumpfer K. L., editors. Before OBJECTIVES: To assess the rates of low-dose aspirin initiation during pregnancy in women with a history of pre-eclampsia, and to Clipboard, Search History, and several other advanced features are temporarily unavailable. The potency of population-based approaches to improving public health has long been recognised (Rose, 1985). Policy makers and public health specialists wanting to improve the mental health of their population now have a range of interventions to choose from, some of these are highlighted in this review. Khazanov GK, Jager-Hyman S, Harrison J, Candon M, Buttenheim A, Pieri MF, Oslin DW, Wolk CB. This site needs JavaScript to work properly. The https:// ensures that you are connecting to the Findings from Two Representative Samples of Puerto Rican Youth. BMJ Nutr Prev Health. Consult the KOL Community Resources ; High-quality guides curated by a team of professionals observing a rigorous review process. Design, Setting, and Participants A review of research. sharing sensitive information, make sure youre on a federal The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 0000013045 00000 n The current clinical model for genetic testing is based on clinical-criteria/family-history (FH) and a pre-defined mutation probability threshold.

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